Lithium-ion cells are complex mechanical systems with poorly understood failure mechanisms under mechanical loading. Independent of their application (e.g. portable electronics or automotive), all cells are made of the same repetitive layers of anode, cathode and separator. Both electrodes are made of metallic foils coated on both sides with a granular media. A liquid electrolyte ensures ion transfer through a porous polymeric separator. From postmortem investigations it is known that under out-of-plane indentation, localization bands are formed below the indenter. Failure of the separator leads to a short circuit and thermal runaway. At the same time, ductile failure of the individual current collectors is also reported. In this study, we investigate and quantify the failure mechanisms in commercial small-format pouch cells (4Ah capacity with NMC/graphite chemistry) using in-situ synchrotron laminography. A newly-developed dedicated loading frame enables performing macroscopic hemispherical indentations. Two in-situ indentations are performed, one with high-quality and one with high field of view. Both comprises more than ten loading steps. In both cases, the voxel size is 3.25µm. The failure in each component is then assessed and quantified through phase segmentation. This insight will help develop numerical model of lithium-ion cell and further enable the design of safe battery system.